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Bayer’s new symptomatic chronic heart failure treatment Verquvo? (vericiguat) approved in EU
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Berlin, Germany, July 21, 2021– The European Commission has granted marketing authorization in the European Union (EU) for vericiguat under the brand name Verquvo. Verquvo (2.5 mg, 5 mg, and 10 mg), a soluble guanylate cyclase (sGC) stimulator, is indicated for symptomatic chronic heart failure in adult patients with reduced ejection fraction who are stabilized after a recent decompensation event requiring intravenous (IV) therapy. It works differently to existing heart failure treatments, providing a specific approach to managing chronic heart failure patients following a decompensation event, also known as a worsening event.
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The 86th China International Pharmaceutical Raw Materials/Intermediates/Packaging/Equipment Fair
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From May 26th to 28th, the 86th China International Pharmaceutical Raw Materials/Intermediates/Packaging/Equipment Fair (API China) was grandly held in the China Import and Export Fair Complex (Guangzhou). The exhibition centered on the theme of "Technology, Safety, Advancement, and Sustainability", comprehensively displaying new products and technologies in the pharmaceutical industry, and in-depth discussion of industry development trends. The 86th API China has an exhibition area of 70,000 square meters, with more than 3,000 booths, and more than 1,100 outstanding domestic and foreign companies participating in the exhibition,Many well-known companies in the pharmaceutical industry are exhibiting at this exhibition, focusing on pharmaceutical raw materials and pharmaceuticals. There are more than 100,000 products in dozens of major categories and more than 300 small categories such as auxiliary materials, pharmaceutical packaging, and pharmaceutical equipment. The exhibition will be held concurrently with the 2021 China Pharmaceutical CXO Conference, the 2021 China Pharmaceutical Industry Technology Annual Conference, the 2020 edition of the "Chinese Pharmacopoeia" executive special training courses, more than 30 high-end forward-looking conferences and forums, nearly 100 industry-renowned experts, and nearly 100 industry hot spots The topics all appeared. At the 86th API China Exhibition, hundreds of Chinese and foreign pharmaceutical machinery companies from more than 20 countries and regions have flourished in this industry festival. Among them, more than 57% of international exhibitors, including Italy Marcosini, OPTIMA Germany Austria Putima, Merck Chemicals (Millipore), Italy CAM, Germany Goninger, Italy CURTI, Italy BREVETTI, etc., domestic exhibitors appeared Shuanghe, Dongfulong, Chutian Technology, Shandong Xinhua, North China Pharmaceutical, Jinzong, Zhejiang Xiaolun, Zhejiang Tianyu, Zhejiang Jiuzhou, Shanghai Tianxiang Jiantai, etc., these Chinese and foreign companies are competing with new technologies, solutions and equipment, showing heavy pharmaceutical industry technology equipment and high-tech products. It provides a direction for the breakthrough and innovation of enterprises in the industry, and also brings more choices to the exhibitors.
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Amino adenine can be used to synthesize atypical DNA
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he latest research by Philippe marliere research group of Paris sackle University reveals the atypical DNA synthesis based on aminoadenine sipoviruses. This research result was published in science recently. Phage genomes contain a wide range of nuclear base chemical diversity in all life forms. Some DNA viruses (such as cyanobacteria, Proteobacteria and actinomycetes) infecting the host have the phenomenon that aminoadenine completely replaces adenine, thus forming three hydrogen bonds with thymine, which violates the Watson Crick pairing rule. Aminoadenine encodes a DNA polymerase homologous to the Klenow fragment of bacterial DNA polymerase I, which contains 3-exonuclease but lacks 5-exonuclease activity. It has been found that aminoadenine is preferentially used instead of adenine in the incorporation of thymine based deoxynucleoside triphosphate. The polymerase gene occurs simultaneously with the gene of a biosynthetic enzyme, which produces aminoadenine deoxynucleotides in various sword spore virus phages. Phylogenetic clustering of polymerase and biosynthetic enzymes indicates that aminoadenine and adenine have been accompanied by DNA replication since ancient times.
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China-Pharm 2021 and API-China 2021 (Guangzhou Exhibition)
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China-Pharm 24th China International Pharmaceutical (industry) exhibition and technical exchange meeting API-China 86th China international pharmaceutical raw materials / intermediates / packaging / Equipment Fair Exhibition time: May 26 to May 28, 2021 Location: China Import and Export Fair Exhibition Hall (Guangzhou Fair Exhibition Hall) No. 380, Yuejiang Middle Road, Guangzhou City, Guangdong Province Host unit: China food and drug International Exchange Center Sinopharm Reed Exhibitions Co., Ltd Introduction: China Pharm and API China will be the largest and most complete pharmaceutical industry exhibition in China. As the organizers, CFDA and reed Sinopharm will take promoting the transformation and upgrading of China's pharmaceutical industry as their own responsibility, and realize the transformation of China from a big pharmaceutical country to a powerful pharmaceutical country. They will build the preferred platform for the exchange of technology, products, resources and information in the global pharmaceutical industry, so as to realize the healthy China dream as soon as possible!
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Postponement notice of 22nd China International Agrochemical and Crop Protection Exhibition
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According to the current control requirements of Shanghai for large-scale public activities, and the epidemic prevention and control measures introduced by various local governments, after taking into full consideration of the opinions from various parties, we prudently decide 22nd China International Agrochemical and Crop Protection Exhibition, 12th China International Fertilizer Show, 22nd China International Agrochemical and Crop Protection Equipment Exhibition,originally scheduled to be held on 3-5 March, 2021, will be postponed to22-24 June, 2021.
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Progress in total synthesis of indoles
win-win Industry news
After the first asymmetric total synthesis of (+) - tronocarpine and the determination of its absolute configuration, Han fushe, a researcher of Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, made important progress in this field. The related research results were published in German Applied Chemistry recently.
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