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On October 12, the 87th API China API Exhibition will meet you in Wuhan!
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The 87th China International Pharmaceutical Raw Materials/Intermediates/Packaging/Equipment Fair (API China) and the 25th China International Pharmaceutical (Industry) Exhibition and Technology Exchange (CHINA-PHARM) will be held on October 12- On the 14th, it was held as scheduled at the Wuhan International Expo Center. The organizing committee of API China and CHINA-PHARM will work closely with Wuhan Municipal Government, Wuhan International Expo Center and other units to ensure the health and safety of the merchants. We will go all out to do business opportunities docking, exhibitor services, visitor invitations and other tasks, and join hands with all colleagues in the Chinese pharmaceutical industry to link the entire pharmaceutical industry chain, stimulate industry innovation and vitality, and jointly build a large platform for China's pharmaceutical internal circulation and a global pharmaceutical industry chain. Birthplace. See you in Wuhan on October 12!
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FDA approves Merck's new drug Belzutifan
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On September 2nd, the Center for Drug Evaluation (CDE) of the National Medical Products Administration of China announced that the new class 1 drug Belzutifan tablets declared by Merck & Co. (MSD) obtained the implied license for clinical trials and plans to be developed for renal cell carcinoma (RCC). Public information shows that the signaling pathway targeted by Belzutifan (MK-6482) is related to hypoxia-inducible factor (HIF-2α). Research on this pathway has won the Nobel Prize in Physiology or Medicine in 2019. At the same time, it is also the first hypoxia-inducible factor inhibitor approved by the FDA. Belzutifan is an investigational, new, potent, and selective oral HIF-2α inhibitor. It is currently being evaluated in multiple clinical studies for the treatment of Von Hippel-Lindau (VHL)-related renal cell carcinoma, advanced renal cell carcinoma, and Patients with advanced solid tumors, etc. Inactivation of VHL (a tumor suppressor protein) protein can abnormally activate HIF-2α protein in cancer patients. HIF-2α factors can accumulate in patients and lead to the formation of benign and malignant tumors.
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Sea freight has skyrocketed: "One box is hard to find" aggravated, foreign trade products are full of warehouses
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On August 11, a positive case of COVID-19 was found at the terminal of Ningbo Zhoushan Port, the world's largest port, which triggered the emergency closure and suspension of operations in the Meishan Port area that day, which made the already tight international capacity worse. Affected by the epidemic and other multiple impacts, the continuously rising ocean freight rates have recently regained a frenzied upward trend. Among them, the spot price of 40-foot standard containers from China to the United States hit a record high of more than US$20,000. In addition to high prices, "a box is hard to find" has forced a large number of foreign trade products to be backlogged in warehouses and cannot be shipped out in time. Products piled up in the corners of warehouses and factories Regarding the recent frenzied increase in sea freight, Zhu Xinchun, general manager of Yiwu Hanlin Electronics Co., Ltd., which sells more than 10 million clock products to the world every year, said frankly that "the impact is extremely large." Raw material price increases and out-of-stock risks remain In addition to the surge in ocean freight, high raw material prices and the risk of shortages are also affecting the profits and subsequent orders of foreign trade companies.
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Bayer’s new symptomatic chronic heart failure treatment Verquvo? (vericiguat) approved in EU
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Berlin, Germany, July 21, 2021– The European Commission has granted marketing authorization in the European Union (EU) for vericiguat under the brand name Verquvo. Verquvo (2.5 mg, 5 mg, and 10 mg), a soluble guanylate cyclase (sGC) stimulator, is indicated for symptomatic chronic heart failure in adult patients with reduced ejection fraction who are stabilized after a recent decompensation event requiring intravenous (IV) therapy. It works differently to existing heart failure treatments, providing a specific approach to managing chronic heart failure patients following a decompensation event, also known as a worsening event.
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The 86th China International Pharmaceutical Raw Materials/Intermediates/Packaging/Equipment Fair
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From May 26th to 28th, the 86th China International Pharmaceutical Raw Materials/Intermediates/Packaging/Equipment Fair (API China) was grandly held in the China Import and Export Fair Complex (Guangzhou). The exhibition centered on the theme of "Technology, Safety, Advancement, and Sustainability", comprehensively displaying new products and technologies in the pharmaceutical industry, and in-depth discussion of industry development trends. The 86th API China has an exhibition area of 70,000 square meters, with more than 3,000 booths, and more than 1,100 outstanding domestic and foreign companies participating in the exhibition,Many well-known companies in the pharmaceutical industry are exhibiting at this exhibition, focusing on pharmaceutical raw materials and pharmaceuticals. There are more than 100,000 products in dozens of major categories and more than 300 small categories such as auxiliary materials, pharmaceutical packaging, and pharmaceutical equipment. The exhibition will be held concurrently with the 2021 China Pharmaceutical CXO Conference, the 2021 China Pharmaceutical Industry Technology Annual Conference, the 2020 edition of the "Chinese Pharmacopoeia" executive special training courses, more than 30 high-end forward-looking conferences and forums, nearly 100 industry-renowned experts, and nearly 100 industry hot spots The topics all appeared. At the 86th API China Exhibition, hundreds of Chinese and foreign pharmaceutical machinery companies from more than 20 countries and regions have flourished in this industry festival. Among them, more than 57% of international exhibitors, including Italy Marcosini, OPTIMA Germany Austria Putima, Merck Chemicals (Millipore), Italy CAM, Germany Goninger, Italy CURTI, Italy BREVETTI, etc., domestic exhibitors appeared Shuanghe, Dongfulong, Chutian Technology, Shandong Xinhua, North China Pharmaceutical, Jinzong, Zhejiang Xiaolun, Zhejiang Tianyu, Zhejiang Jiuzhou, Shanghai Tianxiang Jiantai, etc., these Chinese and foreign companies are competing with new technologies, solutions and equipment, showing heavy pharmaceutical industry technology equipment and high-tech products. It provides a direction for the breakthrough and innovation of enterprises in the industry, and also brings more choices to the exhibitors.
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Amino adenine can be used to synthesize atypical DNA
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he latest research by Philippe marliere research group of Paris sackle University reveals the atypical DNA synthesis based on aminoadenine sipoviruses. This research result was published in science recently. Phage genomes contain a wide range of nuclear base chemical diversity in all life forms. Some DNA viruses (such as cyanobacteria, Proteobacteria and actinomycetes) infecting the host have the phenomenon that aminoadenine completely replaces adenine, thus forming three hydrogen bonds with thymine, which violates the Watson Crick pairing rule. Aminoadenine encodes a DNA polymerase homologous to the Klenow fragment of bacterial DNA polymerase I, which contains 3-exonuclease but lacks 5-exonuclease activity. It has been found that aminoadenine is preferentially used instead of adenine in the incorporation of thymine based deoxynucleoside triphosphate. The polymerase gene occurs simultaneously with the gene of a biosynthetic enzyme, which produces aminoadenine deoxynucleotides in various sword spore virus phages. Phylogenetic clustering of polymerase and biosynthetic enzymes indicates that aminoadenine and adenine have been accompanied by DNA replication since ancient times.
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